Clathrin coat construction in endocytosis

被引：95

作者：

Pearse, BMF

Smith, CJ

Owen, DJ

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Univ London Birkbeck Coll, Dept Crystallog, London WC1E 7HX, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2000年 / 10卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1016/S0959-440X(00)00071-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Electron cryomicroscopy of the clathrin coat and X-ray crystallography of parts of the clathrin heavy chain combine to give a detailed picture of the clathrin molecule, assembled as a cage. Recently determined domain structures of other components of the endocytic machinery, particularly the mu 2 subunit and the alpha-appendage domain of the AP2 adaptor complex, provide important information on the sequence of recognition events involved in the dynamic process of clathrin coat assembly.

引用

收藏

页码：220 / 228

页数：9

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