Synthesis of nitrogen-containing heterocyclic compounds using perfluoro-2-methylpent-2-ene and perfluoro-5-azanon-4-ene

被引：16

作者：

Chi, KW

Furin, GG ^{[1
]}

Gatilov, YV

Bagryanskay, IY

Zhuzhgov, EL

机构：

[1] Russian Acad Sci, Inst Organ Chem, Siberian Div, Novosibirsk 630090, Russia

[2] Univ Ulsan, Dept Chem, Ulsan 680749, South Korea

[3] Novosibirsk State Univ, Novosibirsk 630090, Russia

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2000年 / 103卷 / 02期

关键词：

perfluoro-2-methylpent-2-ene; perfluoro-5-azanon-4-ene; pyrimidine; 2H-pyrido[1,2-a]pyrimidine; 1,3,5]triazine derivatives;

D O I：

10.1016/S0022-1139(99)00310-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Reactions of perfluoro-2-methylpent-2-ena or perfluoro-5-azanon-4-ene with a range of bidentate nitrogen nucleophiles (urea, acet-, benz-, 4-nitrobenz-amidine hydrochloride, 2-aminopyridine, 2-aminobenzimidazole, guanidine) in the presence of Et3N or KOH effectively provided partially fluorinated heterocycles of pyrimidine, 2H-pyrido[1,2-a]pyrimidine and [1,3,5]triazine derivatives. The structure of 2-pentafluoroethyl-3-trifluoromethyl-pyrido[1,2-a]pyrimidin-4-one was further confirmed by the X-ray crystallographic analysis. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：105 / 115

页数：11

共 25 条

[1]

Allen F.H., 1993, CHEM AUTOMAT NEWS, V8, P31

[2]

[Anonymous], 1991, Fluorine in Bioorganic Chemistry

[3]

BELLAMY LJ, 1954, INFRARED SPECTRA COM, P54

[4] 3-(2-[4-(4-FLUOROBENZOYL)PIPERIDINO]-ETHYL)-2-METHYL-4H-PYRIDOL[1,2-A]-PYRIMIDIN-4-ONE (PIRENPERONE) [J].