Differential effects of interleukin-1 beta, interleukin-2, and interferon-gamma on the inducible expression of CYP 1A1 and CYP 1A2 in cultured rabbit hepatocytes

被引：27

作者：

Calleja, C ^{[1
]}

Eeckhoutte, C ^{[1
]}

Larrieu, G ^{[1
]}

Dupuy, J ^{[1
]}

Pineau, T ^{[1
]}

Galtier, P ^{[1
]}

机构：

[1] INRA,LAB PHARMACOL TOXICOL,F-31931 TOULOUSE,FRANCE

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 239卷 / 01期

关键词：

D O I：

10.1006/bbrc.1997.7468

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of interleukin-1 beta, interleukin-2 and interferon-gamma and their combinations were investigated on induced cytochrome P 4501A of cultured rabbit hepatocytes considered 72 h after plating. Without apparent cellular toxicity, these cytokines provoke a significant decrease in TBZ- and BNF-induced P4501A1/2 expression, However specific patterns of action are revealed : IL-1 beta is the most potent cytokine in regard to CYP1A1/2 mRNA suppression whereas IL-2 exerts repressive effects only on P4501A1 induced expression. Although being a strong inhibitor of induced enzymatic activities and protein contents, IFN-gamma exhibits only a weak influence on CYP1A1/2 mRNAs with the exception of its association with interleukins. All these results suggest that IL-1 beta and IL-2 promote mainly a transcriptional repression mechanism whereas IFN-gamma would stimulate a post-transcriptional suppressive pathway. (C) 1997 Academic Press.

引用

页码：273 / 278

页数：6

共 33 条

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