EPIGENETICS AND GENETICS A census of amplified and overexpressed human cancer genes

被引：430

作者：

Santarius, Thomas ^{[1
]}

Shipley, Janet ^{[2
]}

Brewer, Daniel ^{[2
]}

Stratton, Michael R. ^{[1
]}

Cooper, Colin S.

机构：

[1] Wellcome Trust Sanger Ctr, Cambridge CB10 1SA, England

[2] Inst Canc Res, Sutton SM2 5NG, Surrey, England

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 01期

基金：

英国惠康基金;

关键词：

GERM-CELL TUMORS; IMPROVED SURVIVAL PROBABILITY; HUMAN BREAST-CANCER; EXPRESSION ANALYSIS; BLADDER-CANCER; AMPLIFICATION; AMPLICON; IDENTIFICATION; NEUROBLASTOMA; ADOLESCENTS;

D O I：

10.1038/nrc2771

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Integrated genome-wide screens of DNA copy number and gene expression in human cancers have accelerated the rate of discovery of amplified and overexpressed genes. However, the biological importance of most of the genes identified in such studies remains unclear. In this Analysis, we propose a weight-of-evidence based classification system for identifying individual genes in amplified regions that are selected for during tumour development. In a census of the published literature we have identified 77 genes for which there is good evidence of involvement in the development of human cancer.

引用

页码：59 / 64

页数：6

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