Novel treatments for hepatocellular cancer

被引：45

作者：

Kerr, S. H. ^{[1
]}

Kerr, D. J. ^{[1
]}

机构：

[1] Univ Oxford, Dept Clin Pharmacol, Oxford OX3 7DQ, England

来源：

CANCER LETTERS | 2009年 / 286卷 / 01期

关键词：

Hepatocellular; Virus directed enzyme prodrug therapy; INTERNAL RADIATION-THERAPY; COLORECTAL LIVER METASTASES; ENZYME PRODRUG THERAPY; INTRAOPERATIVE DOSIMETRY; E1B-DELETED ADENOVIRUS; Y-90; MICROSPHERES; PHASE-I; CARCINOMA; CHEMOTHERAPY; TRIAL;

D O I：

10.1016/j.canlet.2009.07.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hepatocellular cancer (HCC) has always been considered a therapeutic challenge, given the cytoxic drug resistant nature of the cancer and associated disorder in liver function, reducing the safety of many conventional chemotherapy agents. The Multikinase inhibitor sorafenib has been found to prolong survival in patients with advanced HCC, by around 3 months compared to placebo, but novel treatments need to be explored. Current experimental therapeutic approaches encompass a broad range of science, ranging from intrahepatic irradiation to virus directed immunotherapy. This chapter presents a horizon scan of novel treatments which are currently at early stages of trial development. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：114 / 120

页数：7

共 40 条

[1]

[Anonymous], EXPERT OPIN THERAP P

[2] LIVER RESECTION VERSUS TRANSPLANTATION FOR HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC-PATIENTS [J].

BISMUTH, H ;

CHICHE, L ;

ADAM, R ;

CASTAING, D ;

DIAMOND, T ;

DENNISON, A .

ANNALS OF SURGERY, 1993, 218 (02) :145-151

[3]

Bosch F X., 1997, Liver Cancer, P13

[4]

BURTON MA, 1989, NUCL MED BIOL, V16, P495

[5] SELECTIVE INTERNAL RADIATION-THERAPY - DISTRIBUTION OF RADIATION IN THE LIVER [J].

BURTON, MA ;

GRAY, BN ;

KLEMP, PF ;

KELLEHER, DK ;

HARDY, N .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1989, 25 (10) :1487-1491

[6] SELECTIVE INTERNAL RADIATION-THERAPY - VALIDATION OF INTRAOPERATIVE DOSIMETRY [J].

BURTON, MA ;

GRAY, BN ;

KELLEHER, DK ;

KLEMP, PF .

RADIOLOGY, 1990, 175 (01) :253-255

[7] Tumour dosimetry in human liver following hepatic yttrium-90 microsphere therapy [J].

Campbell, AM ;

Bailey, IH ;

Burton, MA .

PHYSICS IN MEDICINE AND BIOLOGY, 2001, 46 (02) :487-498

[8] Transcatheter arterial chemoembolization for advanced hepatocellular carcinoma with inferior vena cava and right atrial tumors [J].

Chern, M. C. ;

Chuang, V. P. ;

Cheng, T. ;

Lin, Z. H. ;

Lin, Y. M. .

CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 2008, 31 (04) :735-744

[9]

Chung-Faye G, 2001, CLIN CANCER RES, V7, P2662

[10]

CONNORS TA, 1989, CANCER SURV, V8, P693

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