Synthesis of eupomatenoids by three consecutive transition metal-catalyzed cross-coupling reactions

被引：22

作者：

Bach, T ^{[1
]}

Bartels, M ^{[1
]}

机构：

[1] Tech Univ Munich, Lehrstuhl Organ Chem 1, D-85747 Garching, Germany

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 50期

关键词：

D O I：

10.1016/S0040-4039(02)02287-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Six different eupomatenoids (1a-c, 1f-h) were prepared from 2,3,5-tribroinobenzofuran (2) in a concise and high-yielding synthetic sequence. The overall yields vary between 29 and 60% over four to six steps. Key to the success of the syntheses is the high regioselectivity achieved in three Pd(0)- and Ni(0)-catalyzed cross-coupling reactions which were conducted consecutively. The order of substitution at the benzofuran nucleus is C-2, C-5 and C-3. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：9125 / 9127

页数：3

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