A genome scan for QTL influencing milk production and health traits in dairy cattle

被引：173

作者：

Heyen, DW

Weller, JI

Ron, M

Band, M

Beever, JE

Feldmesser, E

Da, Y

Wiggans, GR

VanRaden, PM

Lewin, HA ^{[1
]}

机构：

[1] Univ Illinois, Dept Anim Sci, Edward R Madigan Lab 206, Urbana, IL 61801 USA

[2] Agr Res Org, Volcani Ctr, Inst Anim Sci, IL-50250 Bet Dagan, Israel

[3] ARS, USDA, Anim Improvement Programs Lab, Beltsville, MD 20705 USA

来源：

PHYSIOLOGICAL GENOMICS | 1999年 / 1卷 / 03期

关键词：

genomics; lactation; mastitis;

D O I：

10.1152/physiolgenomics.1999.1.3.165

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

A genome scan was conducted in the North American Holstein-Friesian population for quantitative trait loci (QTL) affecting production and health traits using the granddaughter design. Resource families consisted of 1,068 sons of eight elite sires. Genome coverage was estimated to be 2,551 cM (85%) for 174 genotyped markers. Each marker was tested for effects on milk yield, fat yield, protein yield, fat percentage, protein percentage, somatic cell score, and productive herd life using analysis of variance. Joint analysis of all families identified marker effects on 11 chromosomes that exceeded the genomewide, suggestive, or nominal significance threshold for QTL effects. Large marker effects on fat percentage were found on chromosomes 3 and 14, and multimarker regression analysis was used to refine the position of these QTL. Half-sibling families from Israeli Holstein dairy herds were used in a daughter design to confirm the presence of the QTL for fat percentage on chromosome 14. The QTL identified in this study may be useful for marker-assisted selection and for selection of a refined set of candidate genes affecting these traits.

引用

页码：165 / 175

页数：11

共 68 条

[1] A QTL affecting milk yield and composition maps to bovine chromosome 20: a confirmation [J].

Arranz, JJ ;

Coppieters, W ;

Berzi, P ;

Cambisano, N ;

Grisart, B ;

Karim, L ;

Marcq, F ;

Moreau, L ;

Mezer, C ;

Riquet, J ;

Simon, P ;

Vanmanshoven, P ;

Wagenaar, D ;

Georges, M .

ANIMAL GENETICS, 1998, 29 (02) :107-115

[2] Detection of loci affecting milk production and health traits in an elite US Holstein population using microsatellite markers [J].

Ashwell, MS ;

Rexroad, CE ;

Miller, RH ;

VanRaden, PM ;

Da, Y .

ANIMAL GENETICS, 1997, 28 (03) :216-222

[3]

Ashwell MS, 1996, ANIM GENET, V27, P235, DOI 10.1111/j.1365-2052.1996.tb00484.x

[4] Detection of putative loci affecting conformational type traits in an elite population of united states Holsteins using microsatellite markers [J].

Ashwell, MS ;

Da, Y ;

Vanraden, PM ;

Rexroad, CE ;

Miller, RH .

JOURNAL OF DAIRY SCIENCE, 1998, 81 (04) :1120-1125

[5] Detection of putative loci affecting milk production and composition, health, and type traits in a United States Holstein population [J].

Ashwell, MS ;

Da, Y ;

Van Tassell, CP ;

Vanraden, PM ;

Miller, RH ;

Rexroad, CE .

JOURNAL OF DAIRY SCIENCE, 1998, 81 (12) :3309-3314

[6] A GENETIC-LINKAGE MAP OF THE BOVINE GENOME [J].

BARENDSE, W ;

ARMITAGE, SM ;

KOSSAREK, LM ;

SHALOM, A ;

KIRKPATRICK, BW ;

RYAN, AM ;

CLAYTON, D ;

LI, L ;

NEIBERGS, HL ;

ZHANG, N ;

GROSSE, WM ;

WEISS, J ;

CREIGHTON, P ;

MCCARTHY, F ;

RON, M ;

TEALE, AJ ;

FRIES, R ;

MCGRAW, RA ;

MOORE, SS ;

GEORGES, M ;

SOLLER, M ;

WOMACK, JE ;

HETZEL, DJS .

NATURE GENETICS, 1994, 6 (03) :227-235

[7] A medium-density genetic linkage map of the bovine genome [J].

Barendse, W ;

Vaiman, D ;

Kemp, SJ ;

Sugimoto, Y ;

Armitage, SM ;

Williams, JL ;

Sun, HS ;

Eggen, A ;

Agaba, M ;

Aleyasin, SA ;

Band, M ;

Bishop, MD ;

Buitkamp, J ;

Byrne, K ;

Collins, F ;

Cooper, L ;

Coppettiers, W ;

Denys, B ;

Drinkwater, RD ;

Easterday, K ;

Elduque, C ;

Ennis, S ;

Erhardt, G ;

Ferretti, L ;

Flavin, N ;

Gao, Q ;

Georges, M ;

Gurung, R ;

Harlizius, B ;

Hawkins, G ;

Hetzel, J ;

Hirano, T ;

Hulme, D ;

Jorgensen, C ;

Kessler, M ;

Kirkpatrick, BW ;

Konfortov, B ;

Kostia, S ;

Kuhn, C ;

Lenstra, JA ;

Leveziel, H ;

Lewin, HA ;

Leyhe, B ;

Lil, L ;

Burriel, IM ;

McGraw, RA ;

Miller, JR ;

Moody, DE ;

Moore, SS ;

Nakane, S .

MAMMALIAN GENOME, 1997, 8 (01) :21-28

[8] DETECTION OF LINKAGE BETWEEN MARKER LOCI AND LOCI AFFECTING QUANTITATIVE TRAITS IN CROSSES BETWEEN SEGREGATING POPULATIONS [J].

BECKMANN, JS ;

SOLLER, M .

THEORETICAL AND APPLIED GENETICS, 1988, 76 (02) :228-236

[9] CONTROLLING THE FALSE DISCOVERY RATE - A PRACTICAL AND POWERFUL APPROACH TO MULTIPLE TESTING [J].

BENJAMINI, Y ;

HOCHBERG, Y .

JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES B-STATISTICAL METHODOLOGY, 1995, 57 (01) :289-300

[10]

BISHOP MD, 1994, GENETICS, V136, P619

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