[1] Univ Toronto, Univ Hlth Network, Ontario Canc Inst, Campbell Family Inst Breast Canc Res, Toronto, ON M5G 2C1, Canada
[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada
[3] Hosp Sick Children, Toronto, ON M5G 1X8, Canada
[4] Amgen San Francisco, San Francisco, CA 94080 USA