Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds

被引：131

作者：

Borstnik, K

Paik, IH

Shapiro, TA

Posner, GH

机构：

[1] Johns Hopkins Univ, Dept Chem, Baltimore, MD 21218 USA

[2] Johns Hopkins Univ, Sch Med, Johns Hopkins Malaria Res Inst, Dept Med,Div Clin Pharmacol, Baltimore, MD 21205 USA

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2002年 / 32卷 / 13期

关键词：

trioxanes; chemotherapy; rational design of drugs; malaria; Plasmodium; artemisinin; Yingzhaosu A;

D O I：

10.1016/S0020-7519(02)00195-9

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Mechanism-based rational design and gram-scale chemical synthesis have produced some new trioxane and endoperoxide antimalarial drug candidates that are efficacious and safe. This review summarises recent achievements in this area of peroxide drug development for malaria chemotherapy. (C) 2002 Published by Elsevier Science Ltd. on behalf of Australian Society for Parasitology Inc.

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收藏

页码：1661 / 1667

页数：7

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