The influence of the ε4 allele of the apolipoprotein E gene on childhood IQ, nonverbal reasoning in old age, and lifetime cognitive change

被引：27

作者：

Deary, IJ

Whalley, LJ

St Clair, D

Breen, G

Leaper, S

Lemmon, H

Hayward, C

Starr, JM

机构：

[1] Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland

[2] Univ Aberdeen, Dept Mental Hlth, Aberdeen, Scotland

[3] Med Res Council Med Genet Unit, Edinburgh, Midlothian, Scotland

[4] Univ Edinburgh, Dept Geriatr Med, Edinburgh, Midlothian, Scotland

来源：

INTELLIGENCE | 2003年 / 31卷 / 01期

关键词：

APOE; intelligence; ageing; genetics; dementia; cognition;

D O I：

10.1016/S0160-2896(02)00114-9

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

We examined the influence of APOE epsilon4 allele status on three cognitive outcomes in the same sample of 173 people: (i) IQ (Moray House Test) at age 11 years, (ii) IQ (Raven's Standard Progressive Matrices) at age 77 years, and (iii) change in IQ between age 11 and 77. All participants took part in the Scottish Mental Survey of 1932 and were, followed-up in 1997-1998. There was no significant main effect of gene status on IQ in youth or old age, nor in cognitive change across the lifespan. Sex had no effect on the three cognitive outcome variables and did not interact with APOE epsilon4 allele status. (C) 2003 Elsevier Science Inc. All rights reserved.

引用

页码：85 / 92

页数：8

共 26 条

[1] Education, activity, health, blood pressure and apolipoprotein E as predictors of cognitive change in old age: A review [J].