Comparative study of the epidemiology of rotavirus in children from a community-based birth cohort and a hospital in South India

被引:94
作者
Banerjee, Indrani
Ramani, Sasirekha
Primrose, Beryl
Moses, Prabhakar
Iturriza-Gomara, Miren
Gray, James J.
Jaffar, Shabbar
Monica, Bindhu
Muliyil, Jaya Prakash
Brown, David W.
Estes, Mary K.
Kang, Gagandeep [1 ]
机构
[1] Christian Med Coll & Hosp, Dept Gastrointestinal Sci, Vellore 632004, Tamil Nadu, India
[2] Christian Med Coll & Hosp, Child Hlth Unit 3, Vellore 632004, Tamil Nadu, India
[3] Hlth Protect Agcy, Ctr Infect, Virus Reference Dept, London, England
[4] London Sch Hyg & Trop Med, London WC1, England
[5] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1128/JCM.01882-05
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Rotavirus gastroenteritis is the major cause of severe dehydrating diarrhea in children worldwide. This study compares rotavirus diarrhea in 351 children in a community-based cohort and 343 children admitted to a hospital during the same period. Clinical information and fecal specimens were obtained during diarrheal episodes. Fecal samples were screened for VP6 antigen, and the positive samples were G and P typed by reverse transcription-PCR. Rotavirus was detected in 82/1,152 (7.1%) episodes of diarrhea in the community and 94/343 (27.4%) cases in the hospital. The median age of affected children (7.5 versus 10.5 months) and the mean severity of symptoms (Vesikari score, 7.6 +/- 3.4 versus 11 +/- 2.5) were lower in the community. A larger proportion of children in the community were breast-fed than were children admitted to the hospital (73% versus 34.8%). In the community, the genotypes identified in symptomatic patients, in order of frequency, were G1 (36.5%), G10 (17.1%), G2 (15.9%), and G9 (7.3%) and mixed infections (7.3%). The most common G-P combinations were GIP[8], G2P[4], GIP[4], and G10P[11]. The distribution of G types from hospitalized children was G1 (46.8%), G9 (19.1%), G2 (8.5%), G10 (1.1%), and 4.3% mixed infections. The most common G-P combinations were GIP[81 and G9P[8]. This study documents significant genetic heterogeneity of rotaviruses in the community and the hospital. G10P[11] strains resembling a vaccine candidate strain caused disease in the community, indicating the need for careful epidemiological studies as well as safety studies for the vaccine candidates.
引用
收藏
页码:2468 / 2474
页数:7
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