Virulence of metallo-β-lactamase-producing Pseudomonas aeruginosa in vitro and in vivo

被引：19

作者：

Aoki, S

Hirakata, Y

Kondoh, A

Gotoh, N

Yanagihara, K

Miyazaki, Y

Tomono, K

Yamada, Y

Kohno, S

Kamihira, S

机构：

[1] Nagasaki Univ, Sch Med, Dept Lab Med, Nagasaki 8528501, Japan

[2] Nagasaki Univ, Sch Med, Dept Internal Med 2, Nagasaki 8528501, Japan

[3] Kyoto Pharmaceut Univ, Dept Microbiol, Kyoto 6078414, Japan

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 05期

关键词：

D O I：

10.1128/AAC.48.5.1876-1878.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We evaluated the virulence of Pseudomonas aeruginosa carrying bla(IMP), a metallo-beta-lactamase gene, and the efficacy of ceftazidime, imipenem-cilastatin, and ciprofloxacin in the endogenous bacteremia model. The presence of bla(IMP) did not practically change the virulence of the parent strain, and ciprofloxacin was effective against infection with P. aeruginosa carrying bla(IMP).

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页码：1876 / 1878

页数：3

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