Preimplantation genetic diagnosis

被引：12

作者：

Bick, David P.

Lau, Eduardo C.

机构：

[1] Med Coll Wisconsin, Dept Pediat, Div Med Genet, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Dept Obstet & Gynecol, Milwaukee, WI 53226 USA

[3] Med Coll Wisconsin, Human & Mol Genet Ctr, Milwaukee, WI 53226 USA

来源：

PEDIATRIC CLINICS OF NORTH AMERICA | 2006年 / 53卷 / 04期

关键词：

D O I：

10.1016/j.pcl.2006.05.006

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

This article covers the rapidly advancing field of preimplantation genetic diagnosis (PGD), the molecular genetic analysis of cells taken from embryos formed through in vitro fertilization (IVF). The article focuses on current practices in patient management, relevant IVF and PGD procedures, molecular methods used in the genetic analysis, and technical difficulties that can affect test results. It discusses the growing list of indications for PGD including chromosomal disorders, monogenic disorders and human leukocyte antigen typing typing of embryos. The article also examines some of the emerging technologies being introduced into PGD.

引用

收藏

页码：559 / +

页数：20

相关论文

共 108 条

[31] ESHRE PGD Consortium data collection V: Cycles from January to December 2002 with pregnancy follow-up to October 2003 [J].

Harper, JC ;

Boelaert, K ;

Geraedts, J ;

Harton, G ;

Kearns, WG ;

Moutou, C ;

Muntjewerff, N ;

Repping, S ;

SenGupta, S ;

Scriven, PN ;

Traeger-Synodinos, J ;

Vesela, K ;

Wilton, L ;

Sermon, KD .

HUMAN REPRODUCTION, 2006, 21 (01) :3-21

[32] Controversies and ethical issues in cancer-genetics clinics [J].

Harris, M ;

Winship, I ;

Spriggs, M .

LANCET ONCOLOGY, 2005, 6 (05) :301-310

[33] Polymerase chain reaction/ligase detection reaction/hybridization assays using flow-through microfluidic devices for the detection of low-abundant DNA point mutations [J].

Hashimoto, M ;

Barany, F ;

Soper, SA .

BIOSENSORS & BIOELECTRONICS, 2006, 21 (10) :1915-1923

[34] Clinical application of multiple displacement amplification in preimplantation genetic diagnosis [J].

Hellani, A ;

Coskun, S ;

Tbakhi, A ;

Al-Hassan, S .

REPRODUCTIVE BIOMEDICINE ONLINE, 2005, 10 (03) :376-380

[35] Multiple displacement amplification on single cell and possible PGD applications [J].

Hellani, A ;

Coskun, S ;

Benkhalifa, M ;

Tbakhi, A ;

Sakati, N ;

Al-Odaib, A ;

Ozand, P .

MOLECULAR HUMAN REPRODUCTION, 2004, 10 (11) :847-852

[36]

HOOK EB, 1978, AM J HUM GENET, V30, P19

[37] CHROMOSOMAL ABNORMALITY RATES AT AMNIOCENTESIS AND IN LIVE-BORN INFANTS [J].

HOOK, EB ;

CROSS, PK ;

SCHREINEMACHERS, DM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1983, 249 (15) :2034-2038

[38] Gold nanoparticle probe-based gene expression analysis with unamplified total human RNA -: art. no. e137 [J].

Huber, M ;

Wei, TF ;

Müller, UR ;

Lefebvre, PA ;

Marla, SS ;

Bao, YP .

NUCLEIC ACIDS RESEARCH, 2004, 32 (18) :e137

[39] Widespread aneuploidy revealed by DNA microarray expression profiling [J].

Hughes, TR ;

Roberts, CJ ;

Dai, HY ;

Jones, AR ;

Meyer, MR ;

Slade, D ;

Burchard, J ;

Dow, S ;

Ward, TR ;

Kidd, MJ ;

Friend, SH ;

Marton, MJ .

NATURE GENETICS, 2000, 25 (03) :333-337

[40] Preimplantation genetic diagnosis for β-thalassaemia using sequencing of single cell PCR products to detect mutations and polymorphic loci [J].

Hussey, ND ;

Davis, T ;

Hall, JR ;

Barry, MF ;

Draper, R ;

Norman, RJ ;

Rudzki, Z .

MOLECULAR HUMAN REPRODUCTION, 2002, 8 (12) :1136-1143

← 1 2 3 4 5 6 7 8 9 10 →