HIV-1: Is Nef a PAK animal?

被引：20

作者：

Cullen, BR ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT GENET,DURHAM,NC 27710

来源：

CURRENT BIOLOGY | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/S0960-9822(02)70770-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

HIV-1 Nef is clearly essential for efficient viral replication in vivo, but it has been difficult to determine why. Recent evidence that Nef specifically activates a PAK-dependent signaling cascade may be the first step in defining the mechanism of action of this enigmatic viral protein.

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收藏

页码：1557 / 1559

页数：3

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