Chewing the fat on natural killer T cell development

被引：23

作者：

Godfrey, Dale I. ^{[1
]}

McConville, Malcolm J.

Pellicci, Daniel G.

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Biochem & Mol Biol, Bio21 Mol Sci & Biotechnol Inst, Melbourne, Vic 3010, Australia

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2006年 / 203卷 / 10期

关键词：

D O I：

10.1084/jem.20061787

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer T cells (NKT cells) are selected in the thymus by self-glycolipid antigens presented by CD1d molecules. It is currently thought that one specific component of the lysosomal processing pathway, which leads to the production of isoglobotrihexosylceramide (iGb3), is essential for normal NKT cell development. New evidence now shows that NKT cell development can be disrupted by a diverse range of mutations that interfere with different elements of the lysosomal processing and degradation of glycolipids. This suggests that lysosomal storage diseases (LSDs) in general, rather than one specific defect, can disrupt CD1d antigen presentation, leading to impaired development of NKT cells. JEM © The Rockefeller University Press.

引用

页码：2229 / 2232

页数：4

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