Redox regulation by NRF2 in aging and disease

被引：320

作者：

Schmidlin, Cody J. ^{[1
]}

Dodson, Matthew B. ^{[1
]}

Madhavan, Lalitha ^{[2
,3
,4
]}

Zhang, Donna D. ^{[1
,5
]}

机构：

[1] Univ Arizona, Dept Pharmacol & Toxicol, 1703 E Mabel St, Tucson, AZ 85721 USA

[2] Univ Arizona, Dept Neurol, Tucson, AZ USA

[3] Univ Arizona, Evelyn F McKnight Brain Inst, Tucson, AZ USA

[4] Univ Arizona, Ctr Innovat Brain Sci, Tucson, AZ USA

[5] Univ Arizona, Ctr Canc, Tucson, AZ USA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2019年 / 134卷

关键词：

NRF2; KEAP1; Antioxidant response element (ARE); Redox regulation; Oxidative stress; Age-related pathologies; Neurodegeneration; Cancer; Aging; OXIDATIVE STRESS; ACTIVATION; EXPRESSION; PATHWAY; PROTEASOME; DYSFUNCTION; SENESCENCE; DECLINE; CANCER; GENES;

D O I：

10.1016/j.freeradbiomed.2019.01.016

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

NRF2, a transcription factor that has been deemed the master regulator of cellular redox homeostasis, declines with age. NRF2 transcriptionally upregulates genes that combat oxidative stress; therefore, loss of NRF2 allows oxidative stress to go unmitigated and drive the aging phenotype. Oxidative stress is a common theme among the key features associated with the aging process, collectively referred to as the "Hallmarks of Aging", as it disrupts proteostasis, alters genomic stability, and leads to cell death. In this review, we outline the role that oxidative stress and the reduction of NRF2 play in each of the Hallmarks of Aging, including how they contribute to the onset of neurodegenerative disorders, cancer, and other age-related pathologies.

引用

页码：702 / 707

页数：6

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