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FOXO transcription factors: key regulators of cell fate

被引：187
作者：
Lam, E. W-F. [1 ]
Francis, R. E. [1 ]
Petkovic, M. [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, MRC, Dept Oncol,Canc Res UK Labs, London W12 0NN, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2006年 / 34卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
cell fate; forkhead box O (FOXO); phosphoinositide 3-kinase (PI3K); phosphorylation; tumour;
D O I：
10.1042/BST0340722
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
FOX0 (forkhead box 0) transcription factors are crucial regulators of cell fate. This function of FOX0 proteins relies on their ability to control diverse and at times, opposing cellular functions, such as proliferation, differentiation, DNA repair, defence against oxidative stress damage and apoptosis, in response to hormones, growth factors and other environmental cues. This review discusses our current understanding of the regulation and role of FOX0 transcription factors in determining cell fate and highlights their relevance to tumorigenesis and drug resistance.
引用
收藏
页码：722 / 726
页数：5
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