Role of IGF-I in muscular atrophy of aging

被引：29

作者：

Borst, SE

Lowenthal, DT

机构：

[1] UNIV FLORIDA, DEPT PHARMACOL, GAINESVILLE, FL 32610 USA

[2] UNIV FLORIDA, DEPT MED, GAINESVILLE, FL USA

[3] UNIV FLORIDA, DEPT EXERCISE SCI, GAINESVILLE, FL USA

来源：

ENDOCRINE | 1997年 / 7卷 / 01期

关键词：

growth hormone; insulin-like growth factor I; aging; sarcopenia;

D O I：

10.1007/BF02778065

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Loss of muscle mass and strength are well-known consequences of aging, The growth hormone/IGF-I pathway is both impaired with aging and essential for growth and maintenance of skeletal muscle. Despite this, growth hormone (CH) replacement has not been effective in increasing muscle mass and strength in the elderly. possible explanations for this failure include 1. The presence of other age-related impairments in muscle that prevent the actions of CH and IGF-I and 2. Complications arising from a failure to deliver GH and IGF-I in the physiologically correct manner. This article summarizes the results of clinical trials of GH and IGF-I in the elderly and discusses the current status of strategies for safely and effectively stimulating the GH/IGF-I pathway in this population.

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收藏

页码：61 / 63

页数：3

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