An indicator displacement system for fluorescent detection of phosphate oxyanions under physiological conditions

被引：83

作者：

Hanshaw, RG ^{[1
]}

Hilkert, SM ^{[1
]}

Hua, J ^{[1
]}

Smith, BD ^{[1
]}

机构：

[1] Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 47期

基金：

美国国家科学基金会;

关键词：

fluorescence; displacement assay; pyrophosphate; sensing;

D O I：

10.1016/j.tetlet.2004.09.133

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fluorogenic chemosensing system is described and shown to selectively detect pyrophosphate under physiological conditions. In the best case, pyrophosphate and hydrogen phosphate are capable of displacing a fluorescent courmarin-derived indicator from a bis Zn2+-dipicolylamine coordination compound with association constants of 10(7) and 10(5) M-1, respectively. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：8721 / 8724

页数：4

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