Estimation of vertical and horizontal transmission parameters of Neospora caninum infections in dairy cattle

被引:225
作者
Davison, HC
Otter, A
Trees, AJ
机构
[1] Univ Liverpool, Liverpool Sch Trop Med, Fac Vet Sci, Liverpool L3 5QA, Merseyside, England
[2] Vet Invest Ctr, Vet Labs Agency, Carmarthen SA31 3EZ, Dyfed, Wales
关键词
cattle; ELISA; horizontal and vertical transmission; Neospora caninum; seroconversion;
D O I
10.1016/S0020-7519(99)00129-0
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Transmission parameters of Neospora caninum infections in dairy cattle were determined in six herds with a history of Neospora-associated abortions, using an antibody-detection ELISA to detect evidence of infection. A total of 124 seropositive dams and their calves were tested at calving to estimate vertical transmission, and 154 seronegative heifers were monitored prospectively from birth for evidence of post-natal infection. The probability of vertical transmission was very high; 95.2% (95% confidence interval: 89.8%, 98.2%) of the seropositive dams produced calves that were seropositive prior to consumption of colostrum. In the prospective study, three heifers seroconverted, by 1, 8 and 1 months of age, and the overall incidence rate of seroconversion was 1.9 per 100 heifer-years at risk, ranging from 0 to 4.1 per 100 heifer-years at risk within herds. If heifers with inconclusive ELISA results were included in the analysis, the incidence rate of seroconversion was 3.8 per 100 heifer-years at risk, ranging from 0 to 8.3 per 100 heifer-years at risk within herds. This study showed that Vertical transmission was the major route involved in the spread of N. caninum in these herds, and that there was only a low detectable level of horizontal transmission. However, further studies are needed to provide parasitological evidence of infection in those heifers that seroconverted. (C) 1999 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1683 / 1689
页数:7
相关论文
共 28 条
[1]  
ANDERSON ML, 1995, J AM VET MED ASSOC, V207, P1206
[2]  
Anderson ML, 1997, J AM VET MED ASSOC, V210, P1169
[3]  
Bjorkman C, 1996, J AM VET MED ASSOC, V208, P1441
[4]   BOVINE NEOSPORA ABORTION IN NORTH-EASTERN NEW-SOUTH-WALES [J].
BOULTON, JG ;
GILL, PA ;
COOK, RW ;
FRASER, GC ;
HARPER, P ;
DUBEY, JP .
AUSTRALIAN VETERINARY JOURNAL, 1995, 72 (03) :119-120
[5]   INFLUENCE OF MATERNAL INFECTION ON OFFSPRING RESISTANCE TOWARDS PARASITES [J].
CARLIER, Y ;
TRUYENS, C .
PARASITOLOGY TODAY, 1995, 11 (03) :94-99
[6]   VERTICAL TRANSMISSION OF NEOSPORA-CANINUM IN MICE [J].
COLE, RA ;
LINDSAY, DS ;
BLAGBURN, BL ;
DUBEY, JP .
JOURNAL OF PARASITOLOGY, 1995, 81 (05) :730-732
[7]  
Dannatt L., 1997, Cattle Practice, V5, P335
[8]   Significance of Neospora caninum in British dairy cattle determined by estimation of seroprevalence in normally calving cattle and aborting cattle [J].
Davison, HC ;
Otter, A ;
Trees, AJ .
INTERNATIONAL JOURNAL FOR PARASITOLOGY, 1999, 29 (08) :1189-1194
[9]   Herd-specific and age-specific seroprevalence of Neospora caninum in 14 British dairy herds [J].
Davison, HC ;
French, NP ;
Trees, AJ .
VETERINARY RECORD, 1999, 144 (20) :547-+
[10]   A review of Neospora caninum and neosporosis [J].
Dubey, JP ;
Lindsay, DS .
VETERINARY PARASITOLOGY, 1996, 67 (1-2) :1-59