Analysis of coptisine, berberine and palmatine in adulterated Chinese medicine by capillary electrophoresis-electrospray ion trap mass spectrometry

被引:75
作者
Chen, YR
Wen, KC
Her, GR [1 ]
机构
[1] Natl Taiwan Univ, Dept Chem, Taipei 10764, Taiwan
[2] Natl Labs Food & Drugs, Dept Hlth, Taipei, Taiwan
关键词
pharmaceutical analysis; coptisine; berberine; palmatine; alkaloids;
D O I
10.1016/S0021-9673(99)01115-2
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Chinese medicine preparations contaminated with coptisine, berberine and palmatine were studied by capillary electrophoresis-electrospray ion trap mass spectrometry. The dubious adulterants were identified by their retention times, molecular ions and specific fragment ions produced from collision induced dissociation. The results showed that, in comparison with CE-UV and capillary electrophoresis-electrospray mass spectrometry (CE-ESI-MS), more reliable identification could be achieved with CE-ESI-MS-MS using ion trap mass spectrometry. (C) 2000 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:273 / 280
页数:8
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