Phytochemical and antiinflammatory studies on Terminalia catappa

被引：80

作者：

Fan, YM ^{[1
]}

Xu, LZ ^{[1
]}

Gao, J ^{[1
]}

Wang, Y ^{[1
]}

Tang, XH ^{[1
]}

Zhao, XN ^{[1
]}

Zhang, ZX ^{[1
]}

机构：

[1] Nanjing Univ, Sch Med, Inst Mat Med, Nanjing 210093, Peoples R China

来源：

FITOTERAPIA | 2004年 / 75卷 / 3-4期

关键词：

Terminalia catappa; 2; alpha; 3; beta; 23-trihydroxyurs-12-en-28-oic acid; ursolic acid; topical antiinflammatory activity; 12-O-tetradecanoylphorbol-13-acetate;

D O I：

10.1016/j.fitote.2003.11.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antiinflammatory activity of Terminalia catappa leaves ethanolic extract was studied using 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear edema in acute and chronic models. A bioassay-oriented fractionation procedure showed that the activity concentrates in the chloroform fraction. Ursolic acid (1) and 2alpha,3beta,23-trihydroxyurs-12-en-28-oic acid (2), isolated from the chloroform fraction, exhibited strong antiinflammatory activities. The results suggest that the triterpenic acids 1 and 2 are responsible for the antiinflammatory activity of T. catappa leaves. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：253 / 260

页数：8

共 16 条

[1] MASS SPECTROMETRY IN STRUCTURAL AND STEREOCHEMICAL PROBLEMS .32. PENTACYCLIC TRITERPENES [J].

BUDZIKIEWICZ, H ;

WILSON, JM ;

DJERASSI, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (22) :3688-&

[2] Folk medicine Terminalia catappa and its major tannin component, punicalagin, are effective against bleomycin-induced genotoxicity in Chinese hamster ovary cells [J].

Chen, PS ;

Li, JH ;

Liu, TY ;

Lin, TC .

CANCER LETTERS, 2000, 152 (02) :115-122

[3]

DEYOUNG LM, 1989, AGENTS ACTIONS, V26, P335

[4]

DODDRELL DM, 1974, TETRAHEDRON LETT, P2381

[5] Anti-inflammatory glycoterpenoids from Scrophularia auriculata [J].

Giner, RM ;

Villalba, ML ;

Recio, MC ;

Máñez, S ;

Cerdá-Nicolás, M ;

Ríos, JL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 389 (2-3) :243-252

[6] Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity [J].

Giner-Larza, EM ;

Máñez, S ;

Recio, MC ;

Giner, RM ;

Prieto, JM ;

Cerdá-Nicolás, M ;

Ríos, JL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 428 (01) :137-143

[7]

HUANG MT, 1994, CANCER RES, V54, P701

[8] Effect of triterpenoids on the inflammation induced by protein kinase C activators, neuronally acting irritants and other agents [J].

Huguet, AI ;

Recio, MD ;

Máñez, S ;

Giner, RM ;

Ríos, JL .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 410 (01) :69-81

[9] CONSTITUENTS OF THE LABIATE PLANTS .1. TRITERPENOIDS FROM PRUNELLA VULGARIS [J].

KOJIMA, H ;

OGURA, H .

PHYTOCHEMISTRY, 1986, 25 (03) :729-733

[10] Effects of punicalagin and punicalin on carrageenan-induced inflammation in rats [J].

Lin, CC ;

Hsu, YF ;

Lin, TC .

AMERICAN JOURNAL OF CHINESE MEDICINE, 1999, 27 (3-4) :371-376

← 1 2 →