MicroRNAs and Cancer: Short RNAs Go a Long Way

被引：790

作者：

Ventura, Andrea ^{[3
]}

Jacks, Tyler ^{[1
,2
]}

机构：

[1] MIT, Dept Biol, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[3] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA

来源：

CELL | 2009年 / 136卷 / 04期

关键词：

MIR-17-92; CLUSTER; MIR-200; FAMILY; LET-7; EXPRESSION; GENE; MYC; ACTIVATION; SUPPRESSOR; PROFILES; PROLIFERATION;

D O I：

10.1016/j.cell.2009.02.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, contribute to tumorigenesis. Consistent with this hypothesis, recurrent genetic and epigenetic alterations of individual miRNAs are found in some tumors. Functional studies are now elucidating the mechanism of action of putative oncogenic and tumor suppressor miRNAs.

引用

页码：586 / 591

页数：6

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