History of sleeping sickness (African trypanosomiasis)

被引:28
作者
Cox, FEG [1 ]
机构
[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England
关键词
D O I
10.1016/j.idc.2004.01.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Infections with subspecies of the protozoan parasite Trypanosoma brucei cause important wasting diseases in Africa (nagana in cattle and sleeping sickness in humans). These diseases were little known until the end of the nineteenth century when serious epidemics of nagana were reported and raised concern among the colonial powers. The early history of sleeping sickness revolves around the discovery of the causative organism, its mode of transmission, and its life cycle in the tsetse fly. The history continues into the twentieth century with the discovery of how the parasites evade the immune response, frustrating the development of a vaccine; the failure to develop cheap and effective drugs; and the development of alternative approaches to control the tsetse fly vector.
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页码:231 / +
页数:16
相关论文
共 49 条
[1]  
[Anonymous], NAVY SURG PRACTICAL
[2]  
[Anonymous], PRELIMINARY REPORT T
[3]  
Barrett John, 1997, P347
[4]  
BRAULT J, 1898, JANUS, V3, P36
[5]  
Bruce D, 1915, Br Med J, V1, P1073
[6]  
BRUCE D, 1903, REPORTS SLEEPING SIC, V1, P11
[7]  
BRUCE D, 1903, FURTHER REPORT SLEEP, V4, P3
[8]  
Bruce SirD., 1914, Transactions of the Royal Society of Tropical Medicine and Hygiene London, V8, DOI 10.1016/S0035-9203(14)90016-5
[9]  
CASTELLANI A, 1903, P ROY SOC LONDON, V71, P501
[10]  
Castellani A, 1960, MICROBES MEN MONARCH