Effects of Humoral Immunity and Calreticulin Overexpression on Postoperative Course in Breast Cancer

被引：36

作者：

Eric, Aleksandra ^{[1
]}

Juranic, Zorica ^{[1
]}

Milovanovic, Zorka ^{[1
]}

Markovic, Ivan ^{[1
]}

Inic, Momcilo ^{[1
]}

Stanojevic-Bakic, Nevenka ^{[1
]}

Vojinovic-Golubovic, Vesna ^{[1
]}

机构：

[1] Inst Oncol & Radiol Serbia, Belgrade 11000, Serbia

来源：

PATHOLOGY & ONCOLOGY RESEARCH | 2009年 / 15卷 / 01期

关键词：

Breast cancer; Calreticulin; Humoral immunity; Surgery;

D O I：

10.1007/s12253-008-9112-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim was to investigate whether the humoral immunity and overexpression of calreticulin in tumor tissue determined before surgery, correlate with incidence of metastases in breast cancer patients within two years after operation. Before operation, their humoral immunity and overexpression of caleticulin and Her-2/neu in tumor tissue were analyzed by immunohystochemistry. In 23 patients with metastases in regionally lymph nodes, seven had Her-2/neu overexpression. Among those seven patients, three developed distant metastasis (two women one year and in one woman two years after surgery) and all of them showed the presence of stromal IgG immunoreactivity and overexpression of calreticulin in their tumors tissue. Preliminary data showed that serum IgG immunoreactivity to tumor stroma in combination with overexpression of calreticulin in tumor cells correlate with postoperative appearance of metastases, particularly in the group of patients with Her-2/neu overexpressed tumors and metastases in axillary lymph nodes.

引用

页码：89 / 90

页数：2

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