Expression of a truncated epidermal growth factor receptor-like protein (TEGFR) in ovarian cancer

被引：14

作者：

Ilekis, JV ^{[1
]}

Gariti, J ^{[1
]}

Niederberger, C ^{[1
]}

Scoccia, B ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL MED,DEPT UROL,CHICAGO,IL 60612

来源：

GYNECOLOGIC ONCOLOGY | 1997年 / 65卷 / 01期

关键词：

D O I：

10.1006/gyno.1996.4526

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The epidermal growth factor receptor (EGFR) system has been implicated in the etiology of numerous cancers, including that of ovarian cancer. Elevated levels of EGFR are associated with poor patient prognosis. Moreover, a significant number of ovarian cancers express both the receptor and one of its ligands, suggesting an autocrine mechanism for autonomous tumor growth. Because of the implicated role of the EGFR system in neoplasia, a greater understanding of the factors involved in this system is necessary. We have recently characterized a truncated EGFR-like protein (TEGFR) in human placenta, and we now extend this investigation to ovarian cancer. We report that TEGFR is expressed in ovarian cancer and its level correlates to that of EGFR. Moreover, the level of TEGFR is reduced in metastatic compared to primary tumors. These results suggest that TEGFR may play a role in the EGFR system. (C) 1997 Academic Press.

引用

页码：36 / 41

页数：6

共 43 条

[1] EXPRESSION OF PROTOONCOGENES IN THE PLACENTA [J].