Errors in Quantitative Image Analysis due to Platform-Dependent Image Scaling

被引：51

作者：

Chenevert, Thomas L. ^{[1
]}

Malyarenko, Dariya I. ^{[1
]}

Newitt, David ^{[2
]}

Li, Xin ^{[3
]}

Jayatilake, Mohan ^{[3
]}

Tudorica, Alina ^{[3
]}

Fedorov, Andriy ^{[4
,5
]}

Kikinis, Ron ^{[4
,5
]}

Liu, Tiffany Ting ^{[6
]}

Muzi, Mark ^{[7
]}

Oborski, MatthewJ. ^{[8
]}

Laymon, Charles M. ^{[8
]}

Li, Xia ^{[9
]}

Thomas, Yankeelov ^{[9
]}

Jayashree, Kalpathy-Cramer ^{[10
]}

Mountz, James M. ^{[8
]}

Kinahan, Paul E. ^{[7
]}

Rubin, Daniel L. ^{[6
]}

Fennessy, Fiona ^{[4
,5
]}

Huang, Wei ^{[3
]}

Hylton, Nola ^{[2
]}

Ross, Brian D. ^{[1
]}

机构：

[1] Univ Michigan Hosp, Dept Radiol, Ann Arbor, MI 48109 USA

[2] Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA

[3] Univ Portland, Oregon Hlth & Sci, Portland, OR 97203 USA

[4] Brigham & Womens Hosp, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Boston, MA 02115 USA

[6] Stanford Univ, Stanford, CA 94305 USA

[7] Univ Washington, Seattle, WA USA

[8] Univ Pittsburgh, Pittsburgh, PA USA

[9] Vanderbilt Univ, Inst Imaging Sci, Nashville, TN 37235 USA

[10] Massachusetts Gen Hosp, Boston, MA 02114 USA

来源：

TRANSLATIONAL ONCOLOGY | 2014年 / 7卷 / 01期

基金：

美国国家卫生研究院;

关键词：

INTENSITY NONUNIFORMITY CORRECTION; CLINICAL-TRIALS; QUANTIFICATION; CALIBRATION; UNCERTAINTY; MRI;

D O I：

10.1593/tlo.13811

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

PURPOSE: To evaluate the ability of various software (SW) tools used for quantitative image analysis to properly account for source-specific image scaling employed by magnetic resonance imaging manufacturers. METHODS: A series of gadoteridol-doped distilled water solutions (0%, 0.5%, 1%, and 2% volume concentrations) was prepared for manual substitution into one (of three) phantom compartments to create "variable signal," whereas the other two compartments (containing mineral oil and 0.25% gadoteriol) were held unchanged. Pseudodynamic images were acquired over multiple series using four scanners such that the histogram of pixel intensities varied enough to provoke variable image scaling from series to series. Additional diffusion-weighted images were acquired of an ice-water phantom to generate scanner-specific apparent diffusion coefficient (ADC) maps. The resulting pseudo-dynamic images and ADC maps were analyzed by eight centers of the Quantitative Imaging Network using 16 different SW tools to measure compartment-specific region-of-interest intensity. RESULTS: Images generated by one of the scanners appeared to have additional intensity scaling that was not accounted for by the majority of tested quantitative image analysis SW tools. Incorrect image scaling leads to intensity measurement bias near 100%, compared to nonscaled images. CONCLUSION: Corrective actions for image scaling are suggested for manufacturers and quantitative imaging community.

引用

页码：65 / 71

页数：7

共 18 条

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Diffusion-Weighted Magnetic Resonance Imaging as a Cancer Biomarker: Consensus and Recommendations [J].