Studies on the total synthesis of the macrolide antitumor agent rhizoxin .1. Synthesis of the C3-C13 segment.

被引：24

作者：

White, JD

Nylund, CS

Green, NJ

机构：

[1] Department of Chemistry, Oregon State University, Corvallis

来源：

TETRAHEDRON LETTERS | 1997年 / 38卷 / 42期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0040-4039(97)01780-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An asymmetric synthesis of the C3-C13 segment of rhizoxin is described in which the relative stereochemistry of C7 and C8 is established through a chelation-controlled allylation followed by Mitsunobu inversion, and the pyran ring is constructed by a photochemically initiated 6-exo radical cyclization. (C) 1997 Elsevier Science Ltd.

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页码：7329 / 7332

页数：4

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