Stereoselective synthesis of the C18-C28 fragment of apoptolidin

被引：43

作者：

Schuppan, J ^{[1
]}

Ziemer, B ^{[1
]}

Koert, U ^{[1
]}

机构：

[1] Humboldt Univ, Inst Chem, D-10115 Berlin, Germany

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(99)02134-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient, stereocontrolled synthesis of the C 18-C28 segment of apoptolidin has been achieved. Key steps are a stannous triffate-mediated aldol reaction, the acylation of a Weinreb amide with an E-alkenyl lithium reagent and the dihydroxylation of a C19-C20 double bond. (C) 2000 Elsevier Science Ltd. All rights reserved.

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页码：621 / 624

页数：4

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