C1, C2-ether derivatives of the Amaryllidaceae alkaloid lycorine: Retention of activity of highly lipophilic analogues against cancer cells

被引：54

作者：

Dasari, Ramesh ^{[1
]}

Banuls, Laetitia Moreno Y. ^{[2
]}

Masi, Marco ^{[3
]}

Pelly, Stephen C. ^{[4
]}

Mathieu, Veronique ^{[2
]}

Green, Ivan R. ^{[4
]}

van Otterlo, Willem A. L. ^{[4
]}

Evidente, Antonio ^{[3
]}

Kiss, Robert ^{[2
]}

Kornienko, Alexander ^{[1
]}

机构：

[1] Texas State Univ, Dept Chem & Biochem, San Marcos, TX 78666 USA

[2] Univ Libre Bruxelles, Fac Pharm, Lab Cancerol & Toxicol Expt, Brussels, Belgium

[3] Univ Naples Federico II, Dipartimento Sci Chim, I-80126 Naples, Italy

[4] Univ Stellenbosch, Dept Chem & Polymer Sci, Western Cape, South Africa

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 03期

关键词：

Cancer; Apoptosis resistance; Melanoma; Glioblastoma; Alkaloid; LEUKEMIA-CELLS; APOPTOSIS; NARCICLASINE; RESISTANCE; CHEMISTRY; BIOLOGY; MODELS; BULBS; CYCLE; MICE;

D O I：

10.1016/j.bmcl.2013.12.073

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

As a continuation of the studies aimed at the development of new anticancer agents derived from the Amaryllidaceae alkaloid lycorine, 35 C1, C2-ether analogues of this natural product were synthesized. The compounds were evaluated for antiproliferative activities in vitro in a panel of tumor cell lines with varied levels of apoptosis resistance. A strong correlation between the compound lipophilicity and anticancer activity was observed, indicating that cell permeability properties must be an important determinant in the design of lycorine-based anticancer agents. A theoretical docking model, consistent with the experimental observations, is presented. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：923 / 927

页数：5

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