The role of Homeobox genes in normal hematopoiesis and hematological malignancies

被引：124

作者：

van Oostveen, JW

Bijl, JJ

Raaphorst, FM

Walboomers, JJM

Meijer, CJLM

机构：

[1] Free Univ Amsterdam Hosp, Dept Hematol, NL-1007 MB Amsterdam, Netherlands

[2] Free Univ Amsterdam Hosp, Dept Pathol, NL-1007 MB Amsterdam, Netherlands

来源：

LEUKEMIA | 1999年 / 13卷 / 11期

关键词：

transcription factors; homeobox genes; embryogenesis; hematopoiesis; lymphoma; adhesion;

D O I：

10.1038/sj.leu.2401562

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the last decade it has become clear that homeobox containing genes (HOX genes) not only play a significant role in regulating body formation, but in addition, they are contributing to organization and regulation of hematopoiesis. Modern molecular technologies showed that deregulated expression or disruption of Hox genes can lead to altered characteristics of blood cells or disturbance of blood cell development. In this paper we review the role of HOX proteins in hematopoiesis and leukemogenesis and speculate about their possible target genes and involvement in lymphomagenesis.

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收藏

页码：1675 / 1690

页数：16

相关论文

共 261 条

[1] THE HUMAN HOX GENE FAMILY [J].

ACAMPORA, D ;

DESPOSITO, M ;

FAIELLA, A ;

PANNESE, M ;

MIGLIACCIO, E ;

MORELLI, F ;

STORNAIUOLO, A ;

NIGRO, V ;

SIMEONE, A ;

BONCINELLI, E .

NUCLEIC ACIDS RESEARCH, 1989, 17 (24) :10385-10402

[2] Homeodomain proteins and the regulation of gene expression [J].

Affolter, M. ;

Schier, A. ;

Gehring, W. J. .

CURRENT OPINION IN CELL BIOLOGY, 1990, 2 (03) :485-495

[3] The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors [J].

Akasaka, T ;

Tsuji, K ;

Kawahira, H ;

Kanno, M ;

Harigaya, K ;

Hu, LN ;

Ebihara, Y ;

Nakahata, T ;

Tetsu, O ;

Taniguchi, M ;

Koseki, H .

IMMUNITY, 1997, 7 (01) :135-146

[4] TRANSFORMATION OF AXIAL SKELETON DUE TO OVEREXPRESSION OF BMI-1 IN TRANSGENIC MICE [J].

ALKEMA, MJ ;

VANDERLUGT, NMT ;

BOBELDIJK, RC ;

BERNS, A ;

VANLOHUIZEN, M .

NATURE, 1995, 374 (6524) :724-727

[5] Perturbation of B and T cell development and predisposition to lymphomagenesis in E mu Bmi1 transgenic mice require the Bmi1 RING finger [J].

Alkema, MJ ;

Jacobs, H ;

vanLohuizen, M ;

Berns, A .

ONCOGENE, 1997, 15 (08) :899-910

[6]

ALLEN JD, 1995, J IMMUNOL, V154, P1531

[7]

ALLEN JD, 1993, BLOOD, V81, P3242

[8] Myeloid development is selectively disrupted in PU.1 null mice [J].

Anderson, KL ;

Smith, KA ;

Conners, K ;

McKercher, SR ;

Maki, RA ;

Torbett, BE .

BLOOD, 1998, 91 (10) :3702-3710

[9] Fine mapping of human HOX gene clusters [J].

Apiou, F ;

Flagiello, D ;

Cillo, C ;

Malfoy, B ;

Poupon, MF ;

Dutrillaux, B .

CYTOGENETICS AND CELL GENETICS, 1996, 73 (1-2) :114-115

[10] THE UPSTREAM REGION OF THE HUMAN HOMEOBOX GENE HOX3D IS A TARGET FOR REGULATION BY RETINOIC ACID AND HOX HOMEOPROTEINS [J].

ARCIONI, L ;

SIMEONE, A ;

GUAZZI, S ;

ZAPPAVIGNA, V ;

BONCINELLI, E ;

MAVILIO, F .

EMBO JOURNAL, 1992, 11 (01) :265-277

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