Interfering with apoptosis: Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3

被引：461

作者：

Vito, P ^{[1
]}

Lacana, E ^{[1
]}

DAdamio, L ^{[1
]}

机构：

[1] NIAID,CELLULAR & MOLEC IMMUNOL LAB,T CELL MOLEC BIOL UNIT,BETHESDA,MD 20892

来源：

SCIENCE | 1996年 / 271卷 / 5248期

关键词：

D O I：

10.1126/science.271.5248.521

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca2+-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca2+-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.

引用

页码：521 / 525

页数：5

共 55 条

[1] CELL-GROWTH CYCLE BLOCK OF T-CELL HYBRIDOMAS UPON ACTIVATION WITH ANTIGEN [J].

ASHWELL, JD ;

CUNNINGHAM, RE ;

NOGUCHI, PD ;

HERNANDEZ, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 165 (01) :173-194

[2]

BROWN KR, UNPUB

[3] CELL-AUTONOMOUS FAS (CD95) FAS-LIGAND INTERACTION MEDIATES ACTIVATION-INDUCED APOPTOSIS IN T-CELL HYBRIDOMAS [J].

BRUNNER, T ;

MOGIL, RJ ;

LAFACE, D ;

YOO, NJ ;

MAHBOUBI, A ;

ECHEVERRI, F ;

MARTIN, SJ ;

FORCE, WR ;

LYNCH, DH ;

WARE, CF ;

GREEN, DR .

NATURE, 1995, 373 (6513) :441-444

[4]

CIFONE MG, 1993, J EXP MED, V177, P1547

[5]

COHEN JJ, 1984, J IMMUNOL, V132, P38

[6] A POTENTIAL ROLE FOR APOPTOSIS IN NEURODEGENERATION AND ALZHEIMERS-DISEASE [J].

COTMAN, CW ;

ANDERSON, AJ .

MOLECULAR NEUROBIOLOGY, 1995, 10 (01) :19-45

[7] RIBOSOMAL INITIATION FROM AN ACG CODON IN THE SENDAI VIRUS P/C MESSENGER-RNA [J].

CURRAN, J ;

KOLAKOFSKY, D .

EMBO JOURNAL, 1988, 7 (01) :245-251

[8] IDENTIFICATION OF A NOVEL SERINE THREONINE KINASE AND A NOVEL 15-KD PROTEIN AS POTENTIAL MEDIATORS OF THE GAMMA-INTERFERON-INDUCED CELL-DEATH [J].

DEISS, LP ;

FEINSTEIN, E ;

BERISSI, H ;

COHEN, O ;

KIMCHI, A .

GENES & DEVELOPMENT, 1995, 9 (01) :15-30

[9] AUTOCRINE T-CELL SUICIDE MEDIATED BY APO-1/(FAS/CD95) [J].

DHEIN, J ;

WALCZAK, H ;

BAUMLER, C ;

DEBATIN, KM ;

KRAMMER, PH .

NATURE, 1995, 373 (6513) :438-441

[10] INVOLVEMENT OF AN ICE-LIKE PROTEASE IN FAS-MEDIATED APOPTOSIS [J].

ENARI, M ;

HUG, H ;

NAGATA, S .

NATURE, 1995, 375 (6526) :78-81

← 1 2 3 4 5 6 →