miR-125b Inhibits Connexin43 and Promotes Glioma Growth

被引：57

作者：

Jin, Zheng

Xu, Songbai

Yu, Hongquan

Yang, Boyu

Zhao, Hongguang

Zhao, Gang

机构：

[1] Department of Neurosurgery, First Hospital, Jilin University, Jilin

[2] Department of Radiology, First Hospital, Jilin University, Jilin

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2013年 / 33卷 / 08期

关键词：

MicroRNA; Glioma; Connexin43; mRNA; GLIOBLASTOMA STEM-CELLS; RANDOMIZED PHASE-III; ADJUVANT TEMOZOLOMIDE; 5-YEAR ANALYSIS; PROLIFERATION; EXPRESSION; MICRORNAS; RADIOTHERAPY; CONCOMITANT; SURVIVAL;

D O I：

10.1007/s10571-013-9980-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

MicroRNA is strongly associated with tumor growth and development. This study examined the potential roles of miR-125b in glioma growth. We found that miR-125b promotes glioma cell line growth and clone formation, and protects the glioma cells from apoptosis in vitro. The miR-125b-transfected glioma cells also demonstrated increased growth after in vivo transplantation. We further identified that miR-125b inhibits Connexin43 expression, and the overexpression of Connexin43 antagonizes the effects of miR-125b in cell growth and anti-apoptosis. We conclude that miR-125b regulates glioma growth partly through Connexin43 protein.

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收藏

页码：1143 / 1148

页数：6

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