Some properties of the hazard function of the two-mutation clonal expansion model

被引：129

作者：

Heidenreich, WF ^{[1
]}

Luebeck, EG ^{[1
]}

Moolgavkar, SH ^{[1
]}

机构：

[1] FRED HUTCHINSON CANC RES CTR,DIV PUBL HLTH SCI,SEATTLE,WA 98104

来源：

RISK ANALYSIS | 1997年 / 17卷 / 03期

关键词：

D O I：

10.1111/j.1539-6924.1997.tb00878.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We discuss the hazard function of the two-mutation clonal expansion model with time-dependent parameters, with particular emphasis on identifiability of the parameters. We explicitly construct identifiable parameter combinations, and illustrate the properties of the hazard function under perturbations of the underlying biological parameters.

引用

页码：391 / 399

页数：9

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