Molecular mechanisms of muscular dystrophies: old and new players

被引：235

作者：

Davies, Kay E.

Nowak, Kristen J.

机构：

[1] MRC, Dept Physiol Anat & Genet, Funct Genet Unit, Oxford OX1 3QX, England

[2] Univ Western Australia, Med Res Ctr, Western Australian Inst Med Res, QEII Med Ctr, Nedlands, WA 6009, Australia

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 10期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrm2024

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The study of the muscle cell in the muscular dystrophies (MDs) has shown that mutant proteins result in perturbations of many cellular components. MDs have been associated with mutations in structural proteins, signalling molecules and enzymes as well as mutations that result in aberrant processing of mRNA or alterations in post-translational modifications of proteins. These findings have not only revealed important insights for cell biologists, but have also provided unexpected and exciting new approaches for therapy.

引用

收藏

页码：762 / 773

页数：12

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