Palladium-Catalyzed Domino Direct Arylation/N-Arylation: Convenient Synthesis of Phenanthridines

被引：211

作者：

Candito, David A. ^{[1
]}

Lautens, Mark ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 36期

基金：

加拿大自然科学与工程研究理事会;

关键词：

C-H activation; domino reactions; imines; N-arylation; palladium; TOPOISOMERASE-I; 6-SUBSTITUTED PHENANTHRIDINES; BOND FORMATION; ARYL IODIDES; N-ARYLATION; DERIVATIVES; ISOQUINOLINES; IMINES; IMINOANNULATION; PALLADACYCLES;

D O I：

10.1002/anie.200902400

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Domino reactions possess the ability to generate complexity from simple starting materials. Disclosed is a strategy for the domino direct arylation/N-arylation for the facile construction of diverse phenanthridine derivatives (see scheme; TMS=trimethylsilyl, TBDMS=tertbutyldimethylsilyl). © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：6713 / 6716

页数：4

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