A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide

被引：30

作者：

Chi, Zhenxing ^{[1
]}

Liu, Rutao ^{[1
]}

Zhao, Lingzi ^{[1
]}

Qin, Pengfei ^{[1
]}

Pan, Xingren ^{[1
]}

Sun, Feng ^{[1
]}

Hao, Xiaopeng ^{[2
]}

机构：

[1] Shandong Univ, Sch Environm Sci & Engn, Jinan 250100, Peoples R China

[2] Shandong Univ, State Key Lab Crystal Mat, Jinan 250100, Peoples R China

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2009年 / 72卷 / 03期

关键词：

Silver nanoparticle; Nucleic acids; CPB; Absorption spectrum; Resonance light scattering spectrum; Genotoxicity; SOLID LIPID NANOPARTICLES; FLUORESCENCE PROBE; CARBON NANOTUBES; CYTOTOXICITY; SURFACTANT; PARTICLES; TOXICITY; MICE; DNA;

D O I：

10.1016/j.saa.2008.10.044

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

The environmental genotoxic behavior of silver nanoparticles (nanoAg) combined with the detergent cetylpyridine bromide (CPB) was examined in vitro. The experimental results showed that the genotoxicity of nanoAg itself is weak, but nanoAg shows obvious genotoxicity after combined with CPB. The combined materials have a strong coeffect on calf thymus DNA (ctDNA) at a concentration of 3.3 x 10(-6) gmL(-1) nanoAg and 6.0 x 10(-6) mol L-1 CPB. After the addition of ctDNA to the nanoAg-CPB system, the particles are scattered and the diameter decreases, which indirectly reveal that nanoAg-CPB has genotoxicity. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：577 / 581

页数：5

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