Tumor suppressors and cell metabolism: a recipe for cancer growth

被引:878
作者
Jones, Russell G. [1 ,2 ]
Thompson, Craig B. [3 ,4 ]
机构
[1] McGill Univ, Rosalind & Morris Goodman Canc Ctr, Montreal, PQ H3A 1A3, Canada
[2] McGill Univ, Dept Physiol, Montreal, PQ H3A 1A3, Canada
[3] Univ Penn, Abramson Canc Ctr, Philadelphia, PA 19104 USA
[4] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
基金
加拿大健康研究院; 美国国家卫生研究院;
关键词
Cancer biology; cellular metabolism; tumor suppressors; oncogenes; proliferation; apoptosis; ACTIVATED PROTEIN-KINASE; HYPOXIA-INDUCIBLE FACTOR; PEUTZ-JEGHERS-SYNDROME; ACETYL-COA CARBOXYLASE; ATP CITRATE LYASE; AEROBIC GLYCOLYSIS; C-MYC; PROLYL HYDROXYLASE; LKB1-AMPK PATHWAY; UPSTREAM KINASE;
D O I
10.1101/gad.1756509
中图分类号
Q2 [细胞生物学];
学科分类号
071013 [干细胞生物学];
摘要
Growing tumors face two major metabolic challenges-how to meet the bioenergetic and biosynthetic demands of increased cell proliferation, and how to survive environmental fluctuations in external nutrient and oxygen availability when tumor growth outpaces the delivery capabilities of the existing vasculature. Cancer cells display dramatically altered metabolic circuitry that appears to directly result from the oncogenic mutations selected during the tumorigenic process. An emerging theme in cancer biology is that many of the genes that can initiate tumorigenesis are intricately linked to metabolic regulation. In turn, it appears that a number of well-established tumor suppressors play critical roles in suppressing growth and/or proliferation when intracellular supplies of essential metabolites become reduced. In this review, we consider the potential role of tumor suppressors as metabolic regulators.
引用
收藏
页码:537 / 548
页数:12
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