Galantide improves social memory in rats

被引：7

作者：

Arletti, R

Benelli, A

Cavazzuti, E

Bertolini, A

机构：

[1] Department of Biomedical Sciences, Section of Pharmacology, University of Modena, 41100 Modena

[2] Department of Biomedical Sciences, Section of Pharmacology, University of Modena, 41100 Modena MO

来源：

PHARMACOLOGICAL RESEARCH | 1997年 / 35卷 / 04期

关键词：

galanin; galantide; social recognition;

D O I：

10.1006/phrs.1997.0150

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The role of galanin in memory paradigms has been largely evaluated. The galanin-antagonist galantide, a chimeric peptide obtained from amino acids 1-13 of galanin attached to the C-terminal fragment of bradykinin, has been found to improve social memory in 'social recognition' test when i.c.v. administered at doses varying from 6-6000 nmoles. (C) 1997 The Italian Pharmacological Society.

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收藏

页码：317 / 319

页数：3

相关论文

共 13 条

[1] GALANIN AND GALANIN ANTAGONISTS - MOLECULAR AND BIOCHEMICAL PERSPECTIVES [J].

BARTFAI, T ;

FISONE, G ;

LANGEL, U .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (08) :312-317

[2] M-15 - HIGH-AFFINITY CHIMERIC PEPTIDE THAT BLOCKS THE NEURONAL ACTIONS OF GALANIN IN THE HIPPOCAMPUS, LOCUS-CERULEUS, AND SPINAL-CORD [J].

BARTFAI, T ;

BEDECS, K ;

LAND, T ;

LANGEL, U ;

BERTORELLI, R ;

GIROTTI, P ;

CONSOLO, S ;

XU, XJ ;

WIESENFELDHALLIN, Z ;

NILSSON, S ;

PIERIBONE, VA ;

HOKFELT, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (23) :10961-10965

[3] ALTERATIONS IN CATECHOLAMINE NEURONS OF THE LOCUS COERULEUS IN SENILE DEMENTIA OF THE ALZHEIMER TYPE AND IN PARKINSONS-DISEASE WITH AND WITHOUT DEMENTIA AND DEPRESSION [J].

CHANPALAY, V ;

ASAN, E .

JOURNAL OF COMPARATIVE NEUROLOGY, 1989, 287 (03) :373-392

[4] CO-EXISTENCE OF GALANIN AND ACETYLCHOLINE - IS GALANIN INVOLVED IN MEMORY PROCESSES AND DEMENTIA [J].

CRAWLEY, JN ;

WENK, GL .

TRENDS IN NEUROSCIENCES, 1989, 12 (08) :278-282

[5] MODULATION OF SOCIAL MEMORY IN MALE-RATS BY NEUROHYPOPHYSEAL PEPTIDES [J].

DANTZER, R ;

BLUTHE, RM ;

KOOB, GF ;

LEMOAL, M .

PSYCHOPHARMACOLOGY, 1987, 91 (03) :363-368

[6]

MALIN D H, 1990, Society for Neuroscience Abstracts, V16, P1329

[7] GALANIN ATTENUATES RETENTION OF ONE-TRIAL REWARD LEARNING [J].

MALIN, DH ;

NOVY, BJ ;

LETTBROWN, AE ;

PLOTNER, RE ;

MAY, BT ;

RADULESCU, SJ ;

CROTHERS, MK ;

OSGOOD, LD ;

LAKE, JR .

LIFE SCIENCES, 1992, 50 (13) :939-944

[8] GALANIN ANTAGONIZES ACETYLCHOLINE ON A MEMORY TASK IN BASAL FOREBRAIN-LESIONED RATS [J].

MASTROPAOLO, J ;

NADI, NS ;

OSTROWSKI, NL ;

CRAWLEY, JN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9841-9845

[9] EVIDENCE FOR A ROLE OF THE NEUROPEPTIDE GALANIN IN SPATIAL-LEARNING [J].

OGREN, SO ;

HOKFELT, T ;

KASK, K ;

LANGEL, U ;

BARTFAI, T .

NEUROSCIENCE, 1992, 51 (01) :1-5

[10]

PALAY VC, 1988, BRAIN RES B, V21, P465