Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002

被引:99
作者
Shulman, ST
Tanz, RR
Kabat, W
Kabat, K
Cederlund, E
Patel, D
Li, ZY
Sakota, V
Dale, JB
Beall, B
机构
[1] Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Dept Pediat,Div Infect Dis, Chicago, IL 60614 USA
[2] Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Dept Pediat,Div Gen Acad Pediat, Chicago, IL 60614 USA
[3] Ctr Dis Control & Prevent, Atlanta, GA USA
[4] Vet Affairs Med Ctr, Memphis, TN USA
[5] Univ Tennessee, Ctr Hlth Sci, Memphis, TN 38163 USA
关键词
D O I
10.1086/421949
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Geographic and interseasonal heterogeneity of pharyngeal group A streptococcal (GAS) genotypes (emm types) is poorly characterized. We evaluated emm type and subtype distribution among pediatric pharyngitis isolates obtained from 9 sites in the United States during 2000-2001 (year 1) and from 10 sites in the United States and 1 site in Canada during 2001-2002 (year 2). The 7 predominant types were the same in both years, although their order changed. emm 12, 1, and 28 accounted for 49.2% of year 1 isolates, and emm 1, 12, and 4 accounted for 47.1% of year 2 isolates; 6 types accounted for 72.1% in year 1 and 69.4% in year 2. From year 1 to year 2, the proportions of emm 12 and 28 decreased and emm 1 and 6 increased. Striking intersite and interseasonal variations in the distribution of predominant emm types were observed. We conclude that the most-predominant GAS genotypes were similar for each year despite fluctuations, that intersite and intrasite variations in the distribution of emm types were apparent, and that emm type surveillance is needed as M protein vaccine development proceeds.
引用
收藏
页码:325 / 332
页数:8
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