A unique function for cyclin D3 in early B cell development

被引：101

作者：

Cooper, AB

Sawai, CM

Sicinska, E

Powers, SE

Sicinski, P

Clark, MR ^{[1
]}

Aifantis, I

机构：

[1] Univ Chicago, Dept Med, Rheumatol Sect, Chicago, IL 60637 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Canc Biol, Boston, MA USA

来源：

NATURE IMMUNOLOGY | 2006年 / 7卷 / 05期

关键词：

D O I：

10.1038/ni1324

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During hematopoiesis, stem cell proliferation is dependent on expression of the D-type cyclins. However, little is known about how each cyclin D contributes to the development of specific hematopoietic lineages. Here, analysis of Ccnd1(-/-), Ccnd2(-/-), Ccnd3(-/-) and Ccnd2(-/-) Ccnd3(-/-) mice showed that cyclin D3 was uniquely required for the development of pre-B cells. Transcription of Ccnd3 was dependent on expression of the common gamma-chain. In contrast, expression of the pre-B cell receptor and activation of 'downstream' signaling pathways prevented proteasome-mediated degradation of cyclin D3. Cyclin D3 has a key function in B cell development by integrating cytokine and pre-B cell receptor-dependent signals to expand the pool of pre-B cells that have successfully rearranged immunoglobulin heavy chain.

引用

页码：489 / 497

页数：9

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[1] Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis [J].