Cardiac fatty acid uptake and transport in health and disease

被引：233

作者：

van der Vusse, GJ ^{[1
]}

van Bilsen, M ^{[1
]}

Glatz, JFC ^{[1
]}

机构：

[1] Maastricht Univ, CARIM, Dept Physiol, Maastricht, Netherlands

来源：

CARDIOVASCULAR RESEARCH | 2000年 / 45卷 / 02期

关键词：

cardiomyopathy; diabetes; energy metabolism; heart failure; hypertrophy;

D O I：

10.1016/S0008-6363(99)00263-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fatty acids art: important energy donors for the healthy heart. These substrates are supplied to the myocardium bound to albumin to overcome their low solubility in aqueous solutions such as blood plasma. Transport from the microvasular compartment to the mitochondria inside the cardiomyocytes is most likely a combination of passive and protein-mediated diffusion. Alterations in tissue content of fatty acid-transport proteins may contribute to myocardial diseases such as the diabetic heart, and cardiac hypertrophy and failure. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：279 / 293

页数：15

共 136 条

[1]

Abumrad N, 1998, J LIPID RES, V39, P2309

[2]

ABUMRAD NA, 1993, J BIOL CHEM, V268, P17665

[3]

AILHAUD GP, 1994, WORLD REV NUTR DIET, V75, P35

[4] Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats [J].

Aitman, TJ ;

Glazier, AM ;

Wallace, CA ;

Cooper, LD ;

Norsworthy, PJ ;

Wahid, FN ;

Al-Majali, KM ;

Trembling, PM ;

Mann, CJ ;

Shoulders, CC ;

Graf, D ;

St Lezin, E ;

Kurtz, TW ;

Kren, V ;

Pravenec, M ;

Ibrahimi, A ;

Abumrad, NA ;

Stanton, LW ;

Scott, J .

NATURE GENETICS, 1999, 21 (01) :76-83

[5] CONTRIBUTION OF OXIDATIVE-METABOLISM AND GLYCOLYSIS TO ATP PRODUCTION IN HYPERTROPHIED HEARTS [J].

ALLARD, MF ;

SCHONEKESS, BO ;

HENNING, SL ;

ENGLISH, DR ;

LOPASCHUK, GD .

AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (02) :H742-H750

[6] Heart microvessels and aortic endothelial cells express the 15 kDa heart-type fatty acid-binding proteins [J].

Antohe, F ;

Popov, D ;

Radulescu, L ;

Simionescu, N ;

Börchers, T ;

Spener, F ;

Simionescu, M .

EUROPEAN JOURNAL OF CELL BIOLOGY, 1998, 76 (02) :102-109

[7] Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog [J].

Baillie, AGS ;

Coburn, CT ;

Abumrad, NA .

JOURNAL OF MEMBRANE BIOLOGY, 1996, 153 (01) :75-81

[8]

BANASZAK L, 1994, ADV PROTEIN CHEM, V45, P89

[9] MODELING OF PALMITATE TRANSPORT IN THE HEART [J].

BASSINGTHWAIGHTE, JB ;

NOODLEMAN, L ;

VANDERVUSSE, G ;

GLATZ, JFC .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1989, 88 (1-2) :51-58

[10]

Berk PD, 1996, P SOC EXP BIOL MED, V212, P1

← 1 2 3 4 5 6 7 8 9 10 →