Selection of escape mutants from immune recognition during HIV infection

被引：28

作者：

Bernaschi, M

Castiglione, F

机构：

[1] CNR, Inst Applicaz Calcolo, I-00161 Rome, Italy

[2] Inst Med Bio Math, Bene Ataroth, Israel

来源：

IMMUNOLOGY AND CELL BIOLOGY | 2002年 / 80卷 / 03期

关键词：

cellular automata; computer simulation; human immunodeficiency virus; immune system;

D O I：

10.1046/j.1440-1711.2002.01082.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We present computer simulations of the HIV infection based ona sophisticated cellular automata model of the immune response.The infection progresses following the well-known three-phase dynamicsobserved in patients, that is, acute, silent and acquired immunodeficiency. Antigenic shift and selection of escape viral mutants with low transcriptionrate explain the long term course of the asymptomatic phase, whilethe immunodeficiency status appears to be the consequence of a drasticreduction in T helper cell repertoire.

引用

页码：307 / 313

页数：7

共 30 条

[1] MATHEMATICAL MODEL OF CLONAL SELECTION AND ANTIBODY PRODUCTION .3. CCELLULAR BASIS OF IMMUNOLOGICAL PARALYSIS [J].