Aptamer-based colorimetric probe for cocaine

被引：316

作者：

Stojanovic, MN ^{[1
]}

Landry, DW ^{[1
]}

机构：

[1] Columbia Univ, Dept Med, Div Clin Pharmacol & Expt Therapeut, New York, NY 10032 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 33期

关键词：

D O I：

10.1021/ja0259483

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Complex of an anti-cocaine aptamer and the dye diethylthiotricarbocyanine behaves as a colorimetric sensor with attenuation in absorbance at 760 nm for cocaine in the concentration range of 2-600 μM. Mechanistic studies indicate an intermolecular displacement of the dye as the mechanism of action of the sensor. As the dye is insoluble in buffer, cocaine binding can be followed with the unaided eye as displaced dye precipitates and supernatant decolorizes. Copyright © 2002 American Chemical Society.

引用

页码：9678 / 9679

页数：2

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