Long-term carvedilol therapy increases parasympathetic nervous system activity in chronic congestive heart failure

被引：60

作者：

Goldsmith, RL ^{[1
]}

Bigger, JT ^{[1
]}

Bloomfield, DM ^{[1
]}

Krum, H ^{[1
]}

Steinman, RC ^{[1
]}

SacknerBernstein, J ^{[1
]}

Packer, M ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG, DIV CARDIOL, NEW YORK, NY 10032 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1997年 / 80卷 / 08期

关键词：

D O I：

10.1016/S0002-9149(97)00616-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To determine the effect of beta blockade on parasympathetic nervous system activity, we assessed RR variability during 24-hour Holter monitoring in 10 patients with congestive heart failure before and after 3 to 4 months of treatment with the beta blocker carvedilol. High-frequency-power increased from 26 to 64 ms(2), root-mean-square of successive differences in RR interval increased from 14.3 to 23.7 ms(2), and percentage of absolute differences >50 ms between successive normal RR intervals increased from 0.8% to 4.7%, all p <0.01, indicating a substantial increase in parasympathetic modulation of RR intervals.

引用

页码：1101 / +

页数：1

共 28 条

[1]

ALBRECHT P, 1988, COMPUT CARDIOL, V15, P311

[2] RR VARIABILITY IN HEALTHY, MIDDLE-AGED PERSONS COMPARED WITH PATIENTS WITH CHRONIC CORONARY HEART-DISEASE OR RECENT ACUTE MYOCARDIAL-INFARCTION [J].

BIGGER, JT ;

FLEISS, JL ;

STEINMAN, RC ;

ROLNITZKY, LM ;

SCHNEIDER, WJ ;

STEIN, PK .

CIRCULATION, 1995, 91 (07) :1936-1943

[3] SUSTAINED AUGMENTATION OF PARASYMPATHETIC TONE WITH ANGIOTENSIN-CONVERTING ENZYME-INHIBITION IN PATIENTS WITH CONGESTIVE-HEART-FAILURE [J].

BINKLEY, PF ;

HAAS, GJ ;

STARLING, RC ;

NUNZIATA, E ;

HATTON, PA ;

LEIER, CV ;

CODY, RJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1993, 21 (03) :655-661

[4] PARASYMPATHETIC WITHDRAWAL IS AN INTEGRAL COMPONENT OF AUTONOMIC IMBALANCE IN CONGESTIVE-HEART-FAILURE - DEMONSTRATION IN HUMAN-SUBJECTS AND VERIFICATION IN A PACED CANINE MODEL OF VENTRICULAR FAILURE [J].

BINKLEY, PF ;

NUNZIATA, E ;

HAAS, GJ ;

NELSON, SD ;

CODY, RJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1991, 18 (02) :464-472

[5] BETA-ADRENOCEPTOR ANTAGONISTS INCREASE SINUS ARRHYTHMIA, A VAGOTONIC EFFECT [J].

BITTINER, SB ;

SMITH, SE .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 22 (06) :691-695

[6] PLASMA NOREPINEPHRINE AS A GUIDE TO PROGNOSIS IN PATIENTS WITH CHRONIC CONGESTIVE HEART-FAILURE [J].

COHN, JN ;

LEVINE, TB ;

OLIVARI, MT ;

GARBERG, V ;

LURA, D ;

FRANCIS, GS ;

SIMON, AB ;

RECTOR, T .

NEW ENGLAND JOURNAL OF MEDICINE, 1984, 311 (13) :819-823

[7] DOES THE SYMPATHETIC NERVOUS-SYSTEM INFLUENCE SINUS ARRHYTHMIA IN MAN - EVIDENCE FROM COMBINED AUTONOMIC BLOCKADE [J].

COKER, R ;

KOZIELL, A ;

OLIVER, C ;

SMITH, SE .

JOURNAL OF PHYSIOLOGY-LONDON, 1984, 356 (NOV) :459-464

[8] EFFECT OF ATENOLOL AND DILTIAZEM ON HEART PERIOD VARIABILITY IN NORMAL PERSONS [J].

COOK, JR ;

BIGGER, JT ;

KLEIGER, RE ;

FLEISS, JL ;

STEINMAN, RC ;

ROLNITZKY, LM .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1991, 17 (02) :480-484

[9] DEFECTIVE CARDIAC PARASYMPATHETIC CONTROL IN PATIENTS WITH HEART DISEASE [J].

ECKBERG, DL ;

DRABINSKY, M ;

BRAUNWALD, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1971, 285 (16) :877-+

[10] EFFECT OF METOPROLOL ON MYOCARDIAL-FUNCTION AND ENERGETICS IN PATIENTS WITH NONISCHEMIC DILATED CARDIOMYOPATHY - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY [J].

EICHHORN, EJ ;

HEESCH, CM ;

BARNETT, JH ;

ALVAREZ, LG ;

FASS, SM ;

GRAYBURN, PA ;

HATFIELD, BA ;

MARCOUX, LG ;

MALLOY, CR .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1994, 24 (05) :1310-1320

← 1 2 3 →