Systematic review on noninvasive assessment of subclinical cardiovascular disease in obstructive sleep apnea: new kid on the block!

被引：60

作者：

Ali, Shozab S. ^{[1
,2
]}

Oni, Ebenezer T. ^{[1
]}

Warraich, Haider J. ^{[3
]}

Blaha, Michael J. ^{[5
]}

Blumenthal, Roger S. ^{[5
]}

Karim, Adil ^{[1
]}

Shaharyar, Sameer ^{[1
]}

Jamal, Omar ^{[1
]}

Fialkow, Jonathan ^{[6
,7
]}

Cury, Ricardo ^{[6
,7
]}

Budoff, Matthew J. ^{[8
]}

Agatston, Arthur S. ^{[1
]}

Nasir, Khurram ^{[1
,4
,5
,9
]}

机构：

[1] Baptist Hlth Med Grp, Ctr Prevent & Wellness Res, Miami, FL USA

[2] Univ Manchester, Sch Med, Manchester, Lancs, England

[3] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med, Boston, MA 02215 USA

[4] Florida Int Univ, Robert Stempel Coll Publ Hlth, Dept Epidemiol, Miami, FL 33199 USA

[5] Johns Hopkins Univ, Johns Hopkins Ciccarone Ctr Prevent Heart Dis, Baltimore, MD USA

[6] Baptist Hosp Miami, Miami, FL USA

[7] Baptist Cardiac & Vasc Inst, Miami, FL USA

[8] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Torrance, CA 90509 USA

[9] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL 33199 USA

来源：

SLEEP MEDICINE REVIEWS | 2014年 / 18卷 / 05期

关键词：

Obstructive sleep apnea; Atherosclerosis; Endothelial dysfunction; Cardiovascular disease; Coronary artery calcium; Intima media thickness; Flow-mediated dilation; Pulse wave velocity; INTIMA-MEDIA THICKNESS; CORONARY-HEART-DISEASE; POSITIVE AIRWAY PRESSURE; ARTERY WALL THICKNESS; MIDDLE-AGED MEN; ENDOTHELIAL FUNCTION; CAROTID ATHEROSCLEROSIS; EARLY SIGNS; RISK-FACTOR; INDEPENDENT ASSOCIATION;

D O I：

10.1016/j.smrv.2014.01.004

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Patients with obstructive sleep apnea (OSA) have a high burden of cardiovascular disease (CVD) but a causal relationship between OSA and atherosclerotic CVD remains unclear. We systematically reviewed the literature analyzing the relationship. A review of the Medline database for studies noninvasively evaluating subclinical CVD in OSA was conducted. A total of fifty-two studies were included in this review. Across the studies the prevalence of atherosclerosis, as assessed by coronary artery calcification, carotid intima-media thickness, brachial artery flow-mediated dilation and pulse wave velocity was higher in patients with OSA and correlated with increasing severity and duration of OSA. This study shows OSA is an independent predictor of subclinical CVD as CVD is more likely to occur in patients with long standing and severe OSA. Further research is however necessary to identify specific OSA populations that would benefit from aggressive screening. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：379 / 391

页数：13

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