Synthesis of haptens and their protein conjugates for immunological determination of nitrate esters and nitramines

被引：15

作者：

Blackburn, GM ^{[1
]}

Beadham, IG

Adams, H

Hutchinson, AP

Nicklin, S

机构：

[1] Univ Sheffield, Dept Chem, Krebs Inst Biomolec Res, Sheffield S3 7HF, S Yorkshire, England

[2] Def Evaluat & Res Agcy, Ft Halstead TM14 7BP, Kent, England

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 02期

关键词：

D O I：

10.1039/a906884h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isosteric, isopolar analogues of the nitrate ester pentaerythritol tetranitrate (PETN) and of the cyclic nitramine sym-cyclotrimethylene trinitramine (RDX) having a spacer arm have been linked to carrier proteins to provide immunologically active peptide conjugates. X-Ray structures of RDX, RDX analogue 10, and hapten 14 are compared to establish their conformational relationships.

引用

页码：225 / 230

页数：6

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