Some recent high-performance liquid chromatography separations of the enantiomers of pharmaceuticals and other compounds using the Whelk-O 1 chiral stationary phase

The Whelk-O 1 chiral stationary phase is generally useful for the chromatographic separation of the enantiomers of many classes of analytes including aryl propionic acid non-steroidal anti-inflammatory drugs, aryl epoxides, sulfoxides, alcohols, amides and esters. We herein report some additional recent enantioseparations obtained with this column, including a number of pharmaceuticals such as thalidomide, nicardipine, isradipine, mephenytoin, nirvanol, cyclandelate, bendroflumethiazide, bupivicaine, tolperisone, proglumide, tropicamide and indapamide. The separation of the enantiomers of a collection of additional analytes is also reported, including several compounds containing basic nitrogen, a heretofore difficult class of compounds to resolve with this column.