Polymorphisms of the cytomegalovirus (CMV)-encoded tumor necrosis factor-α and β-chemokine receptors in congenital CMV disease

被引:84
作者
Arav-Boger, R
Willoughby, RE
Pass, RF
Zong, JC
Jang, WJ
Alcendor, D
Hayward, GS
机构
[1] Johns Hopkins Univ, Sch Med, Dept Pediat, Div Infect Dis, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Sch Med, Dept Oncol, Mol Biol Labs, Baltimore, MD 21287 USA
[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Mol Biol Labs, Baltimore, MD 21287 USA
[4] Univ Alabama Birmingham, Dept Pediat, Div Infect Dis, Birmingham, AL USA
关键词
D O I
10.1086/344238
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Some congenital cytomegalovirus (CMV) infections lead to neonatal disease, whereas others have no associated sequelae. To explore a possible role for viral genes as determinants of virulence, portions of the UL144 tumor necrosis factor (TNF)-alpha-like receptor gene, the US28 beta-chemokine receptor gene, and the UL55 envelope glycoprotein B gene from 33 patients with congenital CMV infection were sequenced. Three major UL144 subtypes (A, B, and C) and 2 recombinants (A/C and A/B) were detected. Infection with the least common UL144 subtypes (A, C, A/C, and A/B) was associated with unfavorable disease outcome (P = .04). There was no association between specific subtypes of the US28 and UL55 genes and outcome (P = .864 and P = .765, respectively). Multiple genotypes (implying multiple infections) were detected in tissues from 8 of 10 autopsies. Therefore, polymorphism in the CMV-encoded TNF-alpha-like receptor appears to be associated with congenital CMV disease. Other CMV polymorphisms should be further evaluated for potential relevance to neonatal infection, transplantation, and acquired immunodeficiency syndrome-associated CMV diseases.
引用
收藏
页码:1057 / 1064
页数:8
相关论文
共 25 条
[1]   Coinfection of the immunocompromised but not the immunocompetent host by multiple human cytomegalovirus strains [J].
Baldanti, F ;
Sarasini, A ;
Furione, M ;
Gatti, M ;
Comolli, G ;
Revello, MG ;
Gerna, G .
ARCHIVES OF VIROLOGY, 1998, 143 (09) :1701-1709
[2]   Cytomegalovirus reinfection in young children [J].
Bale, JF ;
Petheram, SJ ;
Souza, IE ;
Murph, JR .
JOURNAL OF PEDIATRICS, 1996, 128 (03) :347-352
[3]  
Bale JF, 2001, J MED VIROL, V65, P90, DOI 10.1002/jmv.2006
[4]  
Benedict CA, 1999, J IMMUNOL, V162, P6967
[5]   Symptomatic congenital cytomegalovirus infection in infants born to mothers with preexisting immunity to cytomegalovirus [J].
Boppana, SB ;
Fowler, KB ;
Britt, WJ ;
Stagno, S ;
Pass, RF .
PEDIATRICS, 1999, 104 (01) :55-60
[6]   Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. [J].
Boppana, SB ;
Rivera, LB ;
Fowler, KB ;
Mach, M ;
Britt, WJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (18) :1366-1371
[7]   Human cytomegalovirus clinical isolates carry at least 19 genes not found in laboratory strains [J].
Cha, TA ;
Tom, E ;
Kemble, GW ;
Duke, GM ;
Mocarski, ES ;
Spaete, RR .
JOURNAL OF VIROLOGY, 1996, 70 (01) :78-83
[8]   MATERNAL AGE AND CONGENITAL CYTOMEGALOVIRUS-INFECTION - SCREENING OF 2 DIVERSE NEWBORN POPULATIONS, 1980-1990 [J].
FOWLER, KB ;
STAGNO, S ;
PASS, RF .
JOURNAL OF INFECTIOUS DISEASES, 1993, 168 (03) :552-556
[9]   FREQUENCY-DISTRIBUTION OF CYTOMEGALOVIRUS ENVELOPE GLYCOPROTEIN GENOTYPES IN BONE-MARROW TRANSPLANT RECIPIENTS [J].
FRIES, BC ;
CHOU, SW ;
BOECKH, M ;
TOROKSTORB, B .
JOURNAL OF INFECTIOUS DISEASES, 1994, 169 (04) :769-774
[10]   Susceptibility to cytomegalovirus infection may be dependent on the cytokine response to the virus [J].
Geist, LJ ;
Hinde, SL .
JOURNAL OF INVESTIGATIVE MEDICINE, 2001, 49 (05) :434-441