Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice

被引:78
作者
Pawlinski, R [1 ]
Pedersen, B [1 ]
Erlich, J [1 ]
Mackman, N [1 ]
机构
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92017 USA
关键词
tissue factor; haemostasis; thrombosis; inflammation; angiogenesis;
D O I
10.1160/TH04-05-0309
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Tissue factor (TF) contributes to a variety of biological processes by generating coagulation proteases and by the activation of protease activated receptors (PARs). Studies, using low TF mice, have provided us with novel insights into the role of TF in tissue-specific haemostasis. Low TF mice exhibit defects in the uterus, placenta, heart and lung, which are all tissues that normally express high levels of TF We propose that these observed defects are primarily due to a reduction in the level of TF to below a critical threshold that is required to maintain adequate haemostasis. Nevertheless, a reduction in TF:FVIIa-dependent signaling may also reduce cell survival and/or compromise the integrity of the vasculature in these organs. Low TF mice are also a useful tool to study the role of TF and the coagulation cascade in other processes, such as thrombosis, inflammation and angiogenesis.
引用
收藏
页码:444 / 450
页数:7
相关论文
共 63 条
[1]   Regulation of vascular endothelial growth factor production and angiogenesis by the cytoplasmic tail of tissue factor [J].
Abe, K ;
Shoji, M ;
Chen, J ;
Bierhaus, A ;
Danave, I ;
Micko, C ;
Casper, K ;
Dillehay, DL ;
Nawroth, PP ;
Rickles, FR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8663-8668
[2]  
Bromberg ME, 1999, THROMB HAEMOSTASIS, V82, P88
[3]   Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation [J].
Bugge, TH ;
Xiao, Q ;
Kombrinck, KW ;
Flick, MJ ;
Holmback, K ;
Danton, HJS ;
Colbert, MC ;
Witte, DP ;
Fujikawa, K ;
Davie, EW ;
Degen, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (13) :6258-6263
[4]  
CALLANDER NS, 1992, CANCER-AM CANCER SOC, V70, P1194, DOI 10.1002/1097-0142(19920901)70:5<1194::AID-CNCR2820700528>3.0.CO
[5]  
2-E
[6]   Tissue factor- and factor X-dependent activation of protease-activated receptor 2 by factor VIIa [J].
Camerer, E ;
Huang, W ;
Coughlin, SR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) :5255-5260
[7]   Combined deficiency of protease-activated receptor-4 and fibrinogen recapitulates the hemostatic defect but not the embryonic lethality of prothrombin deficiency [J].
Camerer, E ;
Duong, DN ;
Hamilton, JR ;
Coughlin, SR .
BLOOD, 2004, 103 (01) :152-154
[8]   Genetic evidence that protease-activated receptors mediate factor Xa signaling in endothelial cells [J].
Camerer, E ;
Kataoka, H ;
Kahn, M ;
Lease, K ;
Coughlin, SR .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (18) :16081-16087
[9]   Role of tissue factor in embryonic blood vessel development [J].
Carmeliet, P ;
Mackman, N ;
Moons, L ;
Luther, T ;
Gressens, P ;
VanVlaenderen, I ;
Demunck, H ;
Kasper, M ;
Breier, G ;
Evrard, P ;
Muller, M ;
Risau, W ;
Edgington, T ;
Collen, D .
NATURE, 1996, 383 (6595) :73-75
[10]   Developmental dynamics of the definitive mouse placenta assessed by stereology [J].
Coan, PM ;
Ferguson-Smith, AC ;
Burton, GJ .
BIOLOGY OF REPRODUCTION, 2004, 70 (06) :1806-1813